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Biology Teaching and Learning Centre · ANU College of Science and Medicine
Have you ever watched a crime show on TV and wondered just how DNA forensic analysis really works? Does everyone really have a unique DNA fingerprint? Have you been tempted to spend $100 to get your own DNA tested? If so, did you know that your test results could help you to trace your ethnic background, find missing relatives and even help the police find a murderer? Have you ever wondered why you are a similar height to your siblings - is it because of your genes, or because of the environment you grew up in? Why do traits vary even when their underlying DNA sequence is exactly the same? What role does genetics play in your risk of developing diseases such as diabetes? This course will introduce you to the principles of population, evolutionary and quantitative genetics. We do this by asking: what can we learn from DNA? In answering this question, we focus on the practical applications of the theory illustrated by human forensic DNA analysis, conservation genetics and evolutionary genetics. In the practical component of the course, students will gain hands-on experience in human forensic DNA profiling in the laboratory, as well as statistical analysis skills across a range of genetic topics. Other topics covered include Next Generation Sequencing and its emerging and far reaching applications in human forensics and conservation genetics; and genetic adaptation including epigenetics and plasticity. Honours Pathway Option (HPO): Entry to the HPO requires a mark of at least 75 in BIOL1003 or BIOL1004 and approval of the course convenor. The options available may vary from year to year.
Assignment 1 - Intro to Forensic DNA Analysis
Learning outcomes 1, 2, 3, 4
Assignment 2 - Statistics of Forensic DNA Analysis
Learning outcomes 1, 2, 3, 4
Assignment 3 - Quantitative Genetics
Learning outcomes 1, 2, 3, 4
Mini-assessment – Small regular assessment tasks spread across the course
Learning outcomes 1, 2, 3, 4
Final Exam
Learning outcomes 1, 2, 3
The expected workload will consist of approximately 130 hours throughout the semester including: - Face-to face component which may consist of 3 x 1 hour lectures/tutorials per week (total 36 hours), 6 x 3 hours of practical and 6 x 1 hour of computer lab sessions throughout the semester. - Approximately 70 hours of self directed study which will include preparation for lectures, presentations and other assessment tasks. Students are expected to actively participate and contribute towards discussions. Other Information This course is designed for both students needing a solid grounding in the principles of population and evolutionary genetics, in order to pursue studies in the fields of genetics, ecology, evolution and computational biology, as well as students who wish to gain a thorough understanding of the practical application of population genetics to human forensic DNA analysis, conservation biology and evolutionary biology. The focus is on principles and concepts, illustrated by examples drawn from studies of human, agricultural, laboratory and wild populations. The course also serves as an excellent introduction to concepts in quantitative biology, teaching students how to break down the calculation of somewhat complex genetic statistics into a series of simple steps that can be performed with a hand calculator, or computer software such as R. Feedback from students who have taken the course consistently highlights gains in confidence and skills for tackling biological calculations of broad relevance to any field in biology, and the value of the skills learned for courses taken later in their degree.
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